By the need for blood pressure levels due to the fact a danger foundation to possess heart attack, i presented analyses stratified because of the history of blood pressure levels at the standard
Neither accessibility potassium medicine (RR=0.78; 95% CI, 0.69 to 1.22) neither accessibility magnesium products (RR=0.85; 95% CI, 0.55 to just one.32) is actually associated with chance of full or ischemic coronary arrest during the analyses adjusted having ages only, but usage of potassium products became strongly inversely related just after modifications to have history of blood pressure level (RR=0.55; 95% CI, 0.thirty five so you can 0.86). Reputation for blood pressure try a strong independent chance factor getting stroke (RR=dos.8; 95% CI, dos.step 1, 3.7) and you may is for the the means to access potassium tablets (46% of the 1248 enhance pages were hypertensives, compared with 19% regarding nonusers). Brand new inverse relationship anywhere between use of potassium drugs and chance of coronary attack inside multivariate analyses try independent out of fat reduction intakes regarding diet, including potassium, magnesium, and dietary fiber, and you can try healthier one of guys which have low dieting consumption out of potassium, magnesium, and you may cereal fibre. The fresh RR comparing the major towards base quintile from potassium consumption is actually 0.39 regarding the reduced tertile off a diet rating, like the step 3 nourishment, 0.57 in the middle, and you may 0.86 in the large tertile. To advance shot the new hypothesis which use regarding potassium products decrease the possibility of stroke, we compared people who advertised using products both in 1986 and you can 1988 which have men just who never utilized medicine. Inside the six kept years of follow-right up, the brand new multivariate RR out-of total stroke certainly complement users try 0.31 (95% CI, 0.12, 0.85; P=0.02); the possibility of coronary attack has also been quicker one of men whom advertised playing with potassium products just during the 1986 (0.46; 95% CI, 0.22, 0.98; P=0.05) yet not certainly one of guys which already been taking pills from inside the 1988 (1.07; 95% CI, 0.55, dos.11).
Inverse relationships ranging from nutrient consumption and you may likelihood of coronary arrest was observed merely certainly hypertensive guys (Figures dos and 3 ). Within the analyses restricted to men bringing diuretics at standard, by yourself or in integration with other antihypertensive medications, the fresh new RR away from coronary arrest having users regarding potassium capsules compared with nonusers was 0.thirty-six (95% CI, 0.18, 0.72; P=0.004). One another dietary fiber and cereal fibre have been rather inversely of the risk out of coronary attack certainly one of hypertensive (RRs getting an excellent 10-grams escalation in consumption was 0.59 and you will 0.33, respectively) but not among normotensive (RRs was indeed 0.88 for) people.
Contained in this high possible investigation, we discovered that boys having diet large into the potassium, cereal fibre, and you may magnesium had a considerably quicker likelihood of coronary attack. These types of inverse relationships was basically just partially told me of the nondietary risk issues but was in fact strong and you may high just certainly guys that have identified blood pressure level. No high contacts was indeed located anywhere between consumption from salt and you can calcium and you will chance of stroke.
5 21 In the an effective ong Japanese boys when you look at the Hawaii, potassium consumption is actually inversely connected with risk of fatal thromboembolic heart attack (RR with the most readily useful versus the base quintile out-of consumption=0.step 3, P for trend=0.002) but not which have threat of nonfatal local married hookups thromboembolic coronary attack (RR=0.87, P to have trend=0.12). dos New weakened relationship having nonfatal occurrences isn’t inconsistent that have a defensive perception, that have become toned down from the mistake on the single twenty-four-hr remember– dependent dietary research. Inside randomized samples, high potassium intake have brought about smaller lack of blood circulation pressure, particularly among hypertensive sufferers. six seven It perception, although not, are smaller than average can only just partially explain the good inverse organization found in this study. Concurrently, modifications getting standard blood pressure got little affect this new estimated RRs related potassium consumption in order to stroke incidence, and you may potassium consumption wasn’t a significant predictor regarding danger of blood circulation pressure contained in this cohort. fourteen Solution systems advised through the suppression out of totally free major development, vascular easy muscle tissue expansion, and you can arterial thrombosis. 22 Yet not, these types of outcomes was in fact developed by fresh expands during the solution potassium concentrations from inside the dogs, in addition to their relevance so you’re able to individuals was unsure. Higher potassium intake may improve serum levels, particularly when consumption is actually lower or sodium consumption is actually higher, 22 and might for this reason slow down the threat of hypokalemia certainly one of males at the high-risk due to diuretic therapy. Diuretic-triggered hypokalemia could raise the danger of ventricular dysrhythmia. 23 twenty four Regardless of if zero improved mortality of heart disease or other explanations is actually located one of boys which have lowest gel potassium in two prior degree, twenty-five twenty-six none is actually adequate to detect a specific association between gel potassium and you can chance of coronary arrest.